What Makes Polysorbate Functional? Impact of Polysorbate 80 Grade and Quality on IgG Stability During Mechanical Stress
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چکیده
منابع مشابه
Influence of α-amilase, trehalose, sorbitol, and polysorbate 80 on the quality of gluten-free bread
Obtaining gluten-free bakery products is technologically difficult and the combination of several ingredients and change of traditional processes is often required. The gluten free dough does not have the ability to retain the gas generated during fermentation and baking, yielding bread with low specific volume and firm and rubbery breadcrumb. Hydrocolloids, emulsifiers, milk products, proteins...
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We have developed and validated an analytical methodology for the quantification of docetaxel and its four major human oxidation metabolites in mouse plasma. We have used this procedure to study the pharmacokinetics and metabolism of docetaxel in female FVB mice, receiving 2.5, 10, or 33 mg/kg of docetaxel by i.v. injection. We have also studied the pharmacokinetics of polysorbate 80, because i...
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The structures of micelles of the surfactant polysorbate 80 (Tween 80) in 0-50% aqueous dimethyl sulfoxide (DMSO) solutions (pH 7.2, ionic strength 2.44 mM) were investigated by means of small-angle X-ray scattering. At DMSO concentrations of 0-20%, core-shell cylinder micelles formed, and at 30-50% DMSO, core-shell discus micelles formed, that is, changing the hydrophobicity of the DMSO solven...
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Oritavancin, a semisynthetic lipoglycopeptide with activity against gram-positive bacteria, has multiple mechanisms of action, including the inhibition of cell wall synthesis and the perturbation of the membrane potential. Approved guidelines for broth microdilution MIC assays with dalbavancin, another lipoglycopeptide, require inclusion of 0.002% polysorbate 80. To investigate the potential im...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2020
ISSN: 0022-3549
DOI: 10.1016/j.xphs.2019.10.015